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The two were in an argument when someone approached them, pulled out a gun and fired shots, police said.
Two cars collided about 2 a.m. Saturday in the 4200 block of West Lake Street. Both vehicles then struck supports for the CTA elevated train tracks. Two people were killed, and three people were hurt.
The man ran into traffic before being struck by a Toyota Prius, police said.
A 16-year-old boy and a 40-year-old man died after being shot about 10:40 a.m. Friday in the 2500 block of West 46th Street, police said.