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It happened about 9:30 p.m. at a residential apartment building in the 1300 block of South Throop Street in the Little Italy/UIC neighborhood, officials said.
The children, all of whom suffered 'minor injuries' were taken to area hospitals after the wreck, which happened at 8:35 a.m. in Will County.
The man, 21, was driving a motorcycle when he ran a red light and ran into a Jeep SUV, police said.
The U.S. State Department issued a "worldwide caution" alert, saying it had learned of an "increased potential for foreign terrorist organization-inspired violence against LGBTQI+ persons and events."