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The victim, only identified as a female, was standing outside her vehicle just after 7 a.m. in the westbound lanes of Interstate 80 near Shorewood when she was fatally struck, Illinois State Police said.
The attack happened about 7 a.m. and left a man and a woman dead, police said.
About 1:40 a.m., she was in a residential complex in the 1200 block of South Central Park Avenue when she was shot in the head, Chicago police said.
About 2:10 a.m., officers responding to calls of a person shot in the 1200 block of West Washburne Avenue and found a 43-year-old man with multiple gunshot wounds to his body, Chicago police said.